As outlined by ACR suggestions, allopurinol is strongly suggested as a first-line urate-reducing medication. Genetic screening is recommended (for the variant identified as HLA B*5801) previous to setting up allopurinol since the carriers of this gene are at an elevated danger of a extreme allergic response.
Dos akan dinaikkan secara beransur-ansur sehingga mencapai paras asid urik yang disasarkan, iaitu kurang daripada 6.0 mg/dL. Bagi pesakit dengan masalah buah pinggang, dos allopurinol dimulakan pada tahap yang rendah dan dipantau dengan teliti.
Probenecid, which allows the kidneys get rid of uric acid from the body. This medicine is a lot less effective than allopurinol or Uloric, and it's not recommended for those with a record of kidney stones.
Steroid seperti prednisolone juga digunakan sebagai rawatan alternatif bagi gout di Malaysia, terutamanya jika NSAIDs atau kolkisin tidak berkesan atau tidak boleh digunakan. Dalam kes-kes di mana kesakitan sangat teruk dan tidak dapat dikawal dengan ubat-ubatan lain, prednisolone pada dos 30 mg setiap hari selama lima hari boleh diberikan.
Jenis ubat ini biasanya diberikan apabila anda mengalami serangan gout akut, dan tidak boleh digunakan dalam jangka masa panjang. Mereka boleh datang dalam bentuk pil atau tablet yang diambil dalam beberapa hari atau suntikan terus ke kawasan sendi yang terjejas. Oleh itu, walaupun ubat ini terdapat di farmasi, anda mesti menebusnya dengan preskripsi doktor.
Baking soda mempu mengurangkan asid urik dalam badan dan mengurangkan keradangan akibat gout. Caranya:
With a primary gout flare-up, shared determination-earning is appropriate in patients at superior possibility as a consequence of a serum urate amount of nine mg per dL (0.fifty four mmol per L) or better, urolithiasis, or stage 3 or greater Persistent kidney disorder. Urate-decreasing therapy hasn't been proven to get valuable for individuals with asymptomatic hyperuricemia.
Untuk kes gout kronik atau serangan teruk, doktor akan menetapkan ubat khusus. Rawatan biasanya dibahagikan kepada dua kategori: ubat untuk serangan akut dan ubat pencegahan jangka panjang.
Pegloticase (Krystexxa) is another option to lower production of uric acid. It is generally reserved for Individuals who have extreme gout and possess not experienced accomplishment with other solutions or can not tolerate them. This medication is given intravenously each and every two months in conjunction with weekly oral methotrexate to prevent Unintended effects and improve success.
Added lbs. Your system tends to make a lot more uric acid, as well as your kidneys have hassle finding rid of it if you're overweight.
Selain itu, terdapat kajian yang menunjukkan potensinya dalam rawatan penyakit lain seperti sirosis hati dan penyakit Behçet, namun penggunaannya dalam kes ini lebih jarang.
A corticosteroid can be injected into your joint that can help Handle ache. Corticosteroids can be injected intravenously or right into a muscle Should the medication can't be taken orally.
Dalam serangan read more gout, kristal asid urik yang tajam terkumpul di sekitar sendi, menyebabkan sel imun bertindak balas secara agresif. Reaksi ini menyebabkan keradangan dan sakit.
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